The 2009 Los Angeles Film Festival, sponsored by Film Independent, is now open for submissions. This is a great and huge film festival, lasting 10 days and hosting 85,000 attendees this year. You have the option of submitting your film through withoutabox.com. They have three deadlines, with the earliest being 5 December. The festival will be held 18-28 June 2009.
The rest of the guidelines are here.